Berberine efficacy against Doxorubicin-induced cardiotoxicity: A systematic review

Cardiotoxicity is one of the main complications chemotherapy that increases morbidity and mortality in cancerous patients. The present systematic review aimed to investigate protective effects berberine (Ber) on doxorubicin (Dox)-induced cardiotoxicity. study protocol was developed following PRISMA statement. An extensive search performed multiple databases, including Embase, PubMed, Cochrane library, Web Science, Scopus. After defining inclusion/exclusion criteria study, 12 records were included. desired data retrieved articles extracted from studies imported into an Excel form ultimately, effects, probable outcomes mechanisms surveyed. By activating sirtuin 1 (SIRT1), Ber caused reduced oxidative damage loss mitochondria integrity cardiomyocytes. It also regulated autophagy apoptosis via down-regulating AMP-activated protein kinase (AMPK), nucleotide-binding oligomerization domain, leucine rich repeat, pyrin domain containing (NLRP) activation. Moreover, increased superoxide dismutase (SOD), catalase (CAT), plasma glutathione peroxidase (GSH-Px) activities, levels malondialdehyde (MDA), up-regulated SIRT3, subsequently stress cardiomyocytes integrity, leading regulating histopathological electrocardiogram changes myocardium. ameliorated DOX-induced calcium ions (Ca2+) iron overload. oxidant inflammatory activity, cardiomyocytes, thus protecting cells against